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2 edition of Studies towards the synthesis of neocarzinostatin chromophore found in the catalog.

Studies towards the synthesis of neocarzinostatin chromophore

Zacharias C. Etheridge

Studies towards the synthesis of neocarzinostatin chromophore

  • 185 Want to read
  • 9 Currently reading

Published .
Written in English


Edition Notes

Statementby Zac C. Etheridge.
SeriesSussex theses ; S 5515
The Physical Object
Pagination186 leaves :
Number of Pages186
ID Numbers
Open LibraryOL22816111M

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Studies towards the synthesis of neocarzinostatin chromophore by Zacharias C. Etheridge Download PDF EPUB FB2

The incorporation results indicated that six carbons of the C 12 naphthoic acid and seven carbons of the C 14 bicyclic diyne/cyclic carbonate ring systems are enriched by [ C]- and [ C]-acetate.

Synthesis of the neocarzinostatin chromophore A core diynene structure using an η 2-hexacarbonyidicobalt mediated Aldol reaction P. Magnus and T. Pitterna, J. Chem. Soc., Chem. The Application of [γ-(Silyloxy)allylidene]ditin to the Efficient Synthesis of the Chromophore of the Neocarzinostatin Dihydroxycyclopentene-Based Dienediyne Core.

European Journal of Organic Cited by: Studies towards the synthesis of Neocarzinostatin chromophore and related analogues.

Thesis (Thesis) Find all citations by this author (default).Author: Khan S. Studies towards the synthesis of the neocarzinostatin chromophore. (Thesis) Doyle V. Publisher: University of Sussex [] Metadata Source: The British Library Type: Thesis.

Abstract. Author: Doyle. Synthetic studies towards the total synthesis of the neocarzinostatin chromophore The chromoprotein Neocarzinostatin (NCS) was the first isolated member of the so- called 'enediyne' class of antibiotics and was found to exhibit broad-spectrum antitumor activity.

The antitumor activity arises solely from the chromophore. Studies Towards the Synthesis of the Neocarzinostatin Chromophore by N.A Neocarzinostatin (NCS), is a member of the class of naturally occurring enediyne antibiotics which Studies towards the synthesis of neocarzinostatin chromophore book potent anti.

Neocarzinostatin chromophore is a naphthoate ester obtained by formal condensation of the carboxy group of 2-hydroxymethoxymethylnaphthoic acid with the 5-hydroxy group of.

Studies towards the asymmetric synthesis of neocarzinostatin chromophore aglycon Author: Soscia, Marco Gennaro. ISNI: Awarding Body: University of Sussex Current Institution:.

Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It consists of two parts, a labile chromophore (the non-protein molecular entity shown at right) and a amino acid protein to which the chromophore.

Title: Congeners of the Enediyne Neocarzinostatin Chromophore: Designed Agents for bulged Nucleic Acid Targets VOLUME: 8 ISSUE: 6 Author(s):Graham B.

Jones, Yiqing Lin, Dong Ma, Ziwei Xiao. Synthetic studies towards the total synthesis of the neocarzinostatin chromophore. By Olivier Gaston Andre Thominet. Abstract. EThOS - Electronic Theses Online ServiceGBUnited Kingdo. In studies directed toward the total synthesis of neocarzinostatin chromophore, the attempted formation of the cyclononadiyne core of the molecule via the intramolecular insertion of an alkylidene.

We present herein our recent efforts towards the synthesis of epoxydiynes which represent an unusual structural feature of the neocarzinostatin chromophore. A number of different routes to these. Neocarzinostatin is a potent antitumor drug consisting of an enediyne chromophore and a protein carrier.

We characterized an intermediate in the equilibrium unfolding pathway of. Summary. Neocarzinostatin (NCS) is a member of a family of chromoprotein antitumor antibiotics. It consists of two noncovalently bound components, a labile chromophore component (NCS-chrom).

The stereoselective synthesis of a bicyclic ring system related to Neocarzinostatin and Kedarcidin Chromophores is described; key steps involve stereo.

(25) Andrew G. Myers, Philip M. Harrington, and Byoung-Mog Kwon. Evidence for Aminoglycoside Participation in Thiol Activation of Neocarzinostatin Chromophore. Synthesis and Reactivity of the. The stereoselective synthesis of a bicyclic ring system related to Neocarzinostatin and Kedarcidin Chromophores is described; key steps involve stereoselective conjugate addition of an enediyne to.

Neocarzinostatin (NCS) is the first enediyne chromoprotein; it consists of a labile chromophore (NCS-Chr) (M r =Fig. 1) (10, 11) that is tightly and noncovalently bound to an apoprotein (apoNCS) ( amino acids).

The chromophore. Abstract. The methanol-extractable, nonprotein chromophore of the antitumor, protein antibiotic neocarzinostatin (NCS) has at least the full activity of the parent compound in inhibiting DNA synthesis. Studies toward the synthesis of natural and unnatural dienediynes 1.

Approaches to a functionalised bicyclic ring system. Tetrahedron55 (9), DOI: /S(99). The formation of products consistent with\ud the intermediacy of the biradical α,3-dehydrotoluene is discussed.\ud \ud In studies directed toward the total synthesis of neocarzinostatin chromophore.

Read "ChemInform Abstract: Synthetic Studies on Compounds Related to Neocarzinostatin Chromophore. Part 2. Synthesis of the Open‐Chain (E)‐ and (Z)‐Dienediyne Systems and Its Application to the Synthesis. Chromophore, a group of atoms and electrons forming part of an organic molecule that causes it to be coloured.

Correlations between the structural features of chemical compounds and their colours have. Neocarzinostatin chromophore: presence of a highly strained ether ring and its reaction with mercaptan and sodium borohydride.

Biochem Biophys Res Commun. Jun 15; (2)– ISHIDA N, MIYAZAKI K, KUMAGAI K, RIKIMARU M. NEOCARZINOSTATIN. General Synthesis. Principal Properties.

Indigoid Chromophore Introduction. General Synthesis. Principal Properties. Cationic Dyes as Chromophores Introduction. General Synthesis. Chemical Structure and Classification. Principal Properties. Polymethine and Related Chromophores Introduction. General Synthesis.

Chemical Synthesis and DNA Photocleavage of the Intercalator–Carbohydrate Hybrid Moiety of the Neocarzinostatin Chromophore. Kazunobu Toshima Prof. Shigeki Takai; Yutaka. Wender, P.A.; "Toward the Ideal Synthesis and and Transformative Therapies: The "Enantioselective Synthesis of Neocarzinostatin Chromophore Aglycon", CHEMTRACTS--ORGANIC Oleary, J.

"A 2nd-Generation Photochemically Activatable Dynemicin Analog: A Concise Synthesis and DNA Cleavage Studies" Synthesis. Neocarzinostatin (NCS) is a protein antitumor antibiotic isolated from Streptomyces carzinostaticus, var The drug is a polypeptide consisting of amino acids (m.w.

10,) linked by two disulfide. In his second year of study, he was awarded an Eastman Kodak Research Fellowship. Upon graduation inhe was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A.

Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin chromophore. Brückner, Reinhard; Suffert, Jean: The Bis(enol triflate) Route to Dienediyne Models of the Biradical Forming and DNA-Cleaving Natural Product Neocarzinostatin Chromophore Full Text PDF ( kb).

The site responsible for the mercaptan (or borohydride)-stimulated DNA scission activity of neocarzinostatin chromophore (NCS-Chrom) is located in the central Csubunit of the molecule.

This has been determined by studies of the characteristic spectral properties of the chromophore. Kedarcidin is a chromoprotein antitumor antibiotic first isolated from an Actinomycete incomprising an ansa-bridged enediyne chromophore (shown) as well as an apoprotein that serves to stabilize the.

Related Books SoS C-1 Building Blocks in Organic Synthesis Intramolecular Ene Approach to the Bicyclic Subunit of Neocarzinostatin Chromophore: Synthetic Route Toward Synthesis of.

Title:Design, Synthesis, and Docking Studies of 4H-Chromene and Chromene Based Azo Chromophores: A Novel Series of Potent Antimicrobial and Anticancer Agents VOLUME: 14 ISSUE:. DELISSER: безкоштовна електронна бібліотека Z-Library | BookSC. Download books for free. Find books.

Biography. SincePlato A. Magriotis, Ph.D., is an Associate Professor of Medicinal Chemistry in the Department of Pharmacy at the University of Patras in Greece and a Research Affiliate with the.

(NMR) studies (12, 13) have also been usedtoderive informationonchromophore binding to apo-NCS. The chromophore components ofACXand MCMappear to be distinct fromNCS-chrom; available ev-idence suggests that eachapoproteinmain-tains specificity for its respective chro-mophore. To establish the chromophore.

Neocarzinostatin is composed of a labile chromophore with DNA-cleaving activity and a stabilizing protein. The chromophore displays marked nonlinearity of the triple bonds and is bound noncovalently in a pocket formed by the two protein domains. The chromophore. The chromophore group of neocarzinostatin is an enediyne, containing a carbon-carbon double bond flanked by two carbon-carbon triple bonds.

Origin. s; earliest use found in Journal Antibiotics. .Neocarzinostatin Chromophore: Structure and Mechanism of DNA Cleavage. Pages Edo, Kiyoto (et al.) Preview Buy Chap95 € Synthesis and Chemistry of Nine-Membered Cyclic Enediyne Chromophores of Chromoprotein Antitumor Antibiotics.

Pages Neocarzinostatin Book .In his second year of study, he was awarded an Eastman Kodak Research Fellowship. Upon graduation inhe was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A.

Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin : $